Continuous renal replacement therapy (CRRT) is a dialysis modality used to treat critically ill, hospitalized patients in the intensive care unit who develop acute kidney injury (AKI). Unlike chronic kidney disease, which occurs slowly over time, AKI often occurs in hospitalized patients treated in an intensive care environment, and it typically occurs over a few hours to a few days.

Benefits of CRRT Short-term benefits

  • Supports the renal system through continuous, gentle removal of excess metabolic waste products, while returning normal electrolyte and acid/base balance.
  • Restores and maintains net neutral fluid balance (prevents accumulation that leads to fluid overload).
  • Delivers continuous nutritional support without concern for fluid restrictions.
  • Provides for optimized drug dosing.

Long-term benefits

  • May improve patient survival rates.2 A 55% survival rate was realized in the largest randomized control trial to date.
  • May increase renal recovery, defined as freedom from dialysis dependence. A 94% recovery rate was achieved in the same large randomized control trial noted above
  • May result in a higher rate of renal recovery when compared to conventional hemodialysis after AKI, as indicated by multiple large clinical studies.